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Fbxw5em1Syli
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Fbxw5em1Syli
Name: F-box and WD-40 domain protein 5; endonuclease-mediated mutation 1, Shuyan Li
MGI ID: MGI:6488664
Gene: Fbxw5  Location: Chr2:25500750-25505470 bp, + strand  Genetic Position: Chr2, 17.31 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
    CRISPR-targeting of exon 2 deleted 31 bp. (J:298305)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbxw5 Mutation:  3 strains or lines available
References
Original:  J:298305 Hui X, et al., FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway. J Mol Cell Cardiol. 2020 Sep 22;151:31-43
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory