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Prodh2em1Jkni
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Prodh2em1Jkni
Name: proline dehydrogenase (oxidase) 2; endonuclease-mediated mutation 1, John Knight
MGI ID: MGI:6472936
Gene: Prodh2  Location: Chr7:30193047-30212827 bp, + strand  Genetic Position: Chr7, 18.36 cM, cytoband A3
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology generated an 85 bp deletion in exon 2 resulting in a frameshift mutation. Western blot analysis confirmed the absence of full-length protein but presence of a truncated 380 bp form that is also seen in wild-type mice. (J:283585)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prodh2 Mutation:  9 strains or lines available
References
Original:  J:283585 Buchalski B, et al., The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165633
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory