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Galnt11tm1Kgth
Targeted Allele Detail
Summary
Symbol: Galnt11tm1Kgth
Name: polypeptide N-acetylgalactosaminyltransferase 11; targeted mutation 1, Kelly G Ten Hagen
MGI ID: MGI:6472727
Gene: Galnt11  Location: Chr5:25427732-25470916 bp, + strand  Genetic Position: Chr5, 12.35 cM
Alliance: Galnt11tm1Kgth page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:287843
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 6, encoding a highly conserved region of the catalytic domain, was replaced with a neomycin selection cassette. (J:287843)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Galnt11 Mutation:  28 strains or lines available
References
Original:  J:287843 Tian E, et al., Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25196-25202
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory