Ins2^tm1.1Mgn
Targeted Allele Detail

Summary

• Symbol: Ins2^tm1.1Mgn
• Name: insulin II; targeted mutation 1.1, Mark A Magnuson
• MGI ID: MGI:6470716
• Synonyms: Ins2^Apple
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^tm1.1Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into exon 2 a lox66 site, nucleosome localized Apple reporter gene (H2B-Apple) with an FRT-flanked puromycin resistance cassette and Lox2272 via RCME on a loxed cassette acceptor (LCA) allele.

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 93 strains or lines available

References

• Original: J:273404 Stancill JS, et al., Transgene-associated human growth hormone expression in pancreatic beta-cells impairs identification of sex-based gene expression differences. Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E196-E209
• All: 4 reference(s)