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Pqbp1tm1.1Hiok
Targeted Allele Detail
Nomenclature
Symbol: Pqbp1tm1.1Hiok
Name: polyglutamine binding protein 1; targeted mutation 1.1, Hitoshi Okazawa
MGI ID: MGI:6467464
Gene: Pqbp1  Location: ChrX:7760758-7765508 bp, - strand  Genetic Position: ChrX, 3.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:279053
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsExons 3 to 7 were flanked by loxP sites and an frt-flanked neomycin selection cassette. The neomycin resistance cassette was removed by crossing with CAG-FLPe recombinase transgenic mice. (J:279053)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pqbp1 Mutation:  4 strains or lines available
References
Original:  J:279053 Ito H, et al., In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry. 2015 Apr;20(4):459-71
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory