Otud3^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Otud3^em1Nju
• Name: OTU domain containing 3; endonuclease-mediated mutation1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6467362
• Synonyms: Otud3^-
• Gene: Otud3 Location: Chr4:138622690-138641256 bp, - strand Genetic Position: Chr4, 70.57 cM, cytoband D3
• Alliance: Otud3^em1Nju page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Introns 1 and 2 were targeted with sgRNAs using CRISPR/Cas9 technology, resulting in the frame-shifting deletion of exon 2. (J:294274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otud3 Mutation: 22 strains or lines available

References

• Original: J:294274 Zhang Z, et al., Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity. Mol Cell. 2020 Jul 16;79(2):304-319.e7
• All: 2 reference(s)