About   Help   FAQ
4930451I11Rikem2Osb
Endonuclease-mediated Allele Detail
Summary
Symbol: 4930451I11Rikem2Osb
Name: RIKEN cDNA 4930451I11 gene; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:6460467
Gene: 4930451I11Rik  Location: Chr7:126429640-126430712 bp, - strand  Genetic Position: Chr7, 69.25 cM
Alliance: 4930451I11Rikem2Osb page
Mutation
origin
Strain of Origin:  (C57BL/6NJcl x DBA/2NJcl)F2
Mutation
description
Allele Type:    Endonuclease-mediated (Modified isoform(s))
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/cas9 mediated recombination created a 246 bp deletion around exon 3, including 88bp from exon 3 and 12bp from exon 4 resulting in an in-frame mutation and premature stop codon at the 85th amino acid. This is predicted to disrupt only the transmembrane isoform. RT-PCR analysis confirmed the absence of the transmembrane form and presence of the secreted form. (J:287619)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any 4930451I11Rik Mutation:  15 strains or lines available
References
Original:  J:287619 Fujihara Y, et al., Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9393-9400
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory