Nell2^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nell2^em1Osb
• Name: NEL-like 2; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6460272
• Gene: Nell2 Location: Chr15:95117321-95426677 bp, - strand Genetic Position: Chr15, 49.39 cM, cytoband F1
• Alliance: Nell2^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• CRISPR-targeted of exons 2 through 4 deleted 54,599 bp and inserted 6 bp. (J:290452)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nell2 Mutation: 45 strains or lines available

References

• Original: J:290452 Kiyozumi D, et al., NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science. 2020 Jun 5;368(6495):1132-1135
• All: 2 reference(s)