Brme1^em1Hirok
Endonuclease-mediated Allele Detail

Summary

• Symbol: Brme1^em1Hirok
• Name: break repair meiotic recombinase recruitment factor 1; endonuclease-mediated mutation 1, Hiroki Shibuya
• MGI ID: MGI:6456788
• Synonyms: Brme1^-
• Gene: Brme1 Location: Chr8:84874654-84899219 bp, + strand Genetic Position: Chr8, 40.35 cM, cytoband C3
• Alliance: Brme1^em1Hirok page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 7 and 8 were targeted with two gRNAs using CRISPR/Cas9 technology. A 386 bp deletion encompassing exon 7 and half of exon 8 results in a null allele. (J:292036)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brme1 Mutation: 24 strains or lines available

References

• Original: J:292036 Zhang J, et al., The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Nat Commun. 2020 Apr 28;11(1):2055
• All: 1 reference(s)