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Lrrc8bem1Bcgen
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Lrrc8bem1Bcgen
Name: leucine rich repeat containing 8 family, member B; endonuclease-mediated mutation 1, Biocytogen LLC
MGI ID: MGI:6456563
Gene: Lrrc8b  Location: Chr5:105563641-105637940 bp, + strand  Genetic Position: Chr5, 50.68 cM
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Undefined
    CRISPR-targeting generated a null allele. (J:288504)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrc8b Mutation:  19 strains or lines available
References
Original:  J:288504 Zhou C, et al., Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19;52(5):767-781.e6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory