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Llcfc1em2Osb
Endonuclease-mediated Allele Detail
Summary
Symbol: Llcfc1em2Osb
Name: LLLL and CFNLAS motif containing 1; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:6437831
Synonyms: Sof1 del
Gene: Llcfc1  Location: Chr6:41661365-41662651 bp, + strand  Genetic Position: Chr6, 19.86 cM, cytoband B2
Alliance: Llcfc1em2Osb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:289149
Parent Cell Line:  EGR-G01 (ES Cell)
Strain of Origin:  (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
    CRISPR/Cas9 technology targeting exons 1 and 2 generated a 1,024 bp deletion. (J:289149)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Llcfc1 Mutation:  15 strains or lines available
References
Original:  J:289149 Noda T, et al., Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory