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Targeted Allele Detail
Symbol: Gpr27tm1Tac
Name: G protein-coupled receptor 27; targeted mutation 1, Taconic
MGI ID: MGI:6423080
Gene: Gpr27  Location: Chr6:99669640-99672027 bp, + strand  Genetic Position: Chr6, 46.22 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:286854
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe single coding exon was replaced with an IRES-lacZ-neomycin resistance cassette and a bovine growth hormone polyadenylation signal, followed by a PGK-puromycin resistance cassette. RT-qPCR analysis confirmed the absence of mRNA expression in the cerebral cortex and pancreatic islets isolated from homozygous mutant mice. Unexpectedly, Gpr27 deletion reduced expression of Eif4e3, a neighboring gene, likely by deleting transcription start sites on the anti-sense strand of the Gpr27 coding exon. (J:286854)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpr27 Mutation:  1 strain or line available
Original:  J:286854 Chopra DG, et al., Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. Sci Rep. 2020 Mar 27;10(1):5629
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
The Jackson Laboratory