Muc4^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Muc4^tm1Unc
• Name: mucin 4; targeted mutation 1, University of North Carolina
• MGI ID: MGI:6416171
• Gene: Muc4 Location: Chr16:32555089-32602761 bp, + strand Genetic Position: Chr16, 23.3 cM
• Alliance: Muc4^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254258
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 981bp of genomic sequence containing the starting methionine in exon 1 was replaced with a reverse-oriented floxed MC1-neo cassette. (J:254258)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Muc4 Mutation: 236 strains or lines available

References

• Original: J:254258 Rowson-Hodel AR, et al., Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer. Oncogene. 2018 Jan 11;37(2):197-207
• All: 3 reference(s)