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Muc4tm1Unc
Targeted Allele Detail
Summary
Symbol: Muc4tm1Unc
Name: mucin 4; targeted mutation 1, University of North Carolina
MGI ID: MGI:6416171
Gene: Muc4  Location: Chr16:32555089-32602761 bp, + strand  Genetic Position: Chr16, 23.3 cM
Alliance: Muc4tm1Unc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:254258
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details981bp of genomic sequence containing the starting methionine in exon 1 was replaced with a reverse-oriented floxed MC1-neo cassette. (J:254258)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Muc4 Mutation:  136 strains or lines available
References
Original:  J:254258 Rowson-Hodel AR, et al., Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer. Oncogene. 2018 Jan 11;37(2):197-207
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/15/2022
MGI 6.22
The Jackson Laboratory