Flvcr2^tm1.2Tda
Targeted Allele Detail

Summary

• Symbol: Flvcr2^tm1.2Tda
• Name: feline leukemia virus subgroup C cellular receptor 2; targeted mutation 1.2, Thomas Arnold
• MGI ID: MGI:6415560
• Synonyms: Flvcr2^{delta,EGFP-tagged}
• Gene: Flvcr2 Location: Chr12:85793313-85860359 bp, + strand Genetic Position: Chr12, 39.8 cM
• Alliance: Flvcr2^tm1.2Tda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287134
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette, mutant loxP site, inverted 2A-EGFP-WPRE-pA cassette with a splice acceptor, loxP site and mutant loxP site were inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2 and inverted the EGFP reporter. (J:287134)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flvcr2 Mutation: 25 strains or lines available

References

• Original: J:287134 Santander N, et al., Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier. J Clin Invest. 2020 May 5
• All: 1 reference(s)