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Mc4rtm1Matsu
Targeted Allele Detail
Summary
Symbol: Mc4rtm1Matsu
Name: melanocortin 4 receptor; targeted mutation 1, Mitsuharu Matsumoto
MGI ID: MGI:6405040
Gene: Mc4r  Location: Chr18:66990776-66993558 bp, - strand  Genetic Position: Chr18, 39.72 cM, cytoband E1
Alliance: Mc4rtm1Matsu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:285412
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn mCherry unit (mCherry and polyoma polyA signal) and neomycin resistance unit (PGK promoter, neomycin resistance gene, and bovine growth hormone polyA signal) were inserted between the transcription start site and the initiation codon of the Mc4r gene with BAC clone RP23-112M22. (J:285412)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mc4r Mutation:  44 strains or lines available
References
Original:  J:285412 Matsumoto M, et al., Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis. PLoS One. 2020;15(1):e0228212
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory