Sell^tm1.1Rpmc
Targeted Allele Detail

Summary

• Symbol: Sell^tm1.1Rpmc
• Name: selectin, lymphocyte; targeted mutation 1.1, Rodger P McEver
• MGI ID: MGI:6403119
• Synonyms: N138G
• Gene: Sell Location: Chr1:163889556-163908354 bp, + strand Genetic Position: Chr1, 71.37 cM
• Alliance: Sell^tm1.1Rpmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249558
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was replaced with a version containing an AAC>GGA substitution, changing asparagine codon 176 to a glycine codon (p.N138G on mature peptide, p.N176G on prepropeptide). The loxP site flanked neomycin resistance gene and STOP cassette that was inserted into intron 2 was removed through subsequent cre-mediated recombination. (J:249558)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sell Mutation: 41 strains or lines available

References

• Original: J:249558 Liu Z, et al., L-selectin mechanochemistry restricts neutrophil priming in vivo. Nat Commun. 2017 May 12;8:15196
• All: 1 reference(s)