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Tg(CAG-ACE2)AC70Ctkt
Transgene Detail
Nomenclature
Symbol: Tg(CAG-ACE2)AC70Ctkt
Name: transgene insertion AC70, Chien-Te K Tseng
MGI ID: MGI:6402828
Synonyms: AC70
Transgene: Tg(CAG-ACE2)AC70Ctkt  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-ACE2)AC70Ctkt expresses 1 gene
 
Mutation detailsThe human ACE2 cDNA is under the control of the CAG promoter (consisting of the cytomegalovirus immediate-early enhancer and the chicken beta-actin promoter). Five lines (AC12, AC22, AC50, AC63, and AC70) were generated with two, AC70 and AC63 further analyzed. Transgene expression is much higher in the AC70 line than in the AC63 line. (J:117824)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:117824 Tseng CT, et al., Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. J Virol. 2007 Feb;81(3):1162-73
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory