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Tg(CAG-DPP4)4Yuzh
Transgene Detail
Nomenclature
Symbol: Tg(CAG-DPP4)4Yuzh
Name: transgene insertion 4, Yusen Zhou
MGI ID: MGI:6402443
Transgene: Tg(CAG-DPP4)4Yuzh  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-DPP4)4Yuzh expresses 1 gene
 
Mutation detailsA codon-optimized human DPP4 is under the control of the CAG promoter. Four lines (1-4) were generated. Line 4 shows high lung viral titer after infection with Middle East respiratory coronavirus. (J:286175)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:286175 Zhao G, et al., Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus. PLoS One. 2015;10(12):e0145561
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/19/2021
MGI 6.16
The Jackson Laboratory