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Tg(KRT18-DPP4)3Pbmj
Transgene Detail
Nomenclature
Symbol: Tg(KRT18-DPP4)3Pbmj
Name: transgene insertion 3, Paul B McCray Jr
MGI ID: MGI:6402178
Synonyms: K18-hDPP4
Transgene: Tg(KRT18-DPP4)3Pbmj  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J x SJL/J
Transgene
description
Transgene Type:    Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT18-DPP4)3Pbmj expresses 1 gene
 
Mutation detailsA FLAG epitope-tagged human DPP4 cDNA is under the control of the human cytokeratin 18 promoter. The promoter directs expression of the Middle East respiratory coronavirus receptor in airway and alveolar epithelial cells, as well as epithelial of the liver, kidney, and gastrointestinal tract, and some nervous system cells. Four lines were generated. (J:285467)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:285467 Li K, et al., Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4. J Infect Dis. 2016 Mar 1;213(5):712-22
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory