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Dpp4tm1.1(DPP4)Pbmj
Targeted Allele Detail
Nomenclature
Symbol: Dpp4tm1.1(DPP4)Pbmj
Name: dipeptidylpeptidase 4; targeted mutation 1.1, Paul B McCray Jr
MGI ID: MGI:6400999
Synonyms: hDPP4-KI
Gene: Dpp4  Location: Chr2:62330073-62412231 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:242025
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Dpp4tm1.1(DPP4)Pbmj expresses 1 gene
 
Mutation detailsExons 10-12 (from codon I264 in exon 10 to codon V340 in exon 12) of the mouse were replaced with the corresponding human exons of 10-12 which comprise the critical Middle East respiratory syndrome coronavirus (MERS-CoV) receptor. A neomycin resistance gene flanked by FRT sites and a puromycin resistance gene flanked by F3 sites were inserted in intron 9 and intron 12, respectively. The selection markers were removed via Flp-mediated recombination. (J:242025)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:  43 strains or lines available
References
Original:  J:242025 Li K, et al., Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3119-E3128
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory