About   Help   FAQ
Dpp4em1Rba
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Dpp4em1Rba
Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 1, Ralph S Baric
MGI ID: MGI:6400423
Synonyms: 288/330+
Gene: Dpp4  Location: Chr2:62160417-62242575 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C2-D
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/Cas9 technology introduced two amino acid changes, an alanine to leucine substitution at amino acid 288 (A288L) in exon 10 and a threonine to arginine substitution at amino acid 330 (T330R) in exon 11. These two changes match the human sequence, making mice susceptible to Middle East respiratory syndrome coronavirus infection and replication. (J:279834)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpp4 Mutation:  47 strains or lines available
References
Original:  J:279834 Cockrell AS, et al., A mouse model for MERS coronavirus-induced acute respiratory distress syndrome. Nat Microbiol. 2016 Nov 28;2:16226
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/14/2021
MGI 6.17
The Jackson Laboratory