Dpp4^em1Rba
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dpp4^em1Rba
• Name: dipeptidylpeptidase 4; endonuclease-mediated mutation 1, Ralph S Baric
• MGI ID: MGI:6400423
• Synonyms: 288/330⁺
• Gene: Dpp4 Location: Chr2:62160417-62242575 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C2-D
• Alliance: Dpp4^em1Rba page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced two amino acid changes, an alanine to leucine substitution at amino acid 288 (A288L) in exon 10 and a threonine to arginine substitution at amino acid 330 (T330R) in exon 11. These two changes match the human sequence, making mice susceptible to Middle East respiratory syndrome coronavirus infection and replication. (J:279834)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpp4 Mutation: 73 strains or lines available

References

• Original: J:279834 Cockrell AS, et al., A mouse model for MERS coronavirus-induced acute respiratory distress syndrome. Nat Microbiol. 2016 Nov 28;2:16226
• All: 10 reference(s)