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Dnase1tm2092.1Arte
Targeted Allele Detail
Summary
Symbol: Dnase1tm2092.1Arte
Name: deoxyribonuclease I; targeted mutation 2092.1, TaconicArtemis
MGI ID: MGI:6400348
Gene: Dnase1  Location: Chr16:3855007-3857888 bp, + strand  Genetic Position: Chr16, 2.37 cM, cytoband A1-A3
Alliance: Dnase1tm2092.1Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277126
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 to 8 were replaced with a Puromycin selection cassette flanked by F3 sites. Flp-mediated recombination removed the selection cassette. RT-PCR confirmed the absence of the Dnase1 transcript but presence of the overlapping Trap1 transcript. (J:277126)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnase1 Mutation:  28 strains or lines available
References
Original:  J:277126 Kenny EF, et al., Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease. Eur J Immunol. 2019 Apr;49(4):590-599
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory