9030622O22Rik^em1Eem
Endonuclease-mediated Allele Detail

Summary

• Symbol: 9030622O22Rik^em1Eem
• Name: RIKEN cDNA 9030622O22 gene; endonuclease-mediated mutation 1, Edward E Morrisey
• MGI ID: MGI:6392887
• Synonyms: Falcor^-
• Gene: 9030622O22Rik Location: Chr2:147786386-147882176 bp, - strand Genetic Position: Chr2, 73.22 cM
• Alliance: 9030622O22Rik^em1Eem page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted the promoter, transcriptional start site and exon 1. RNA-seq and qPCR from the lung epithelium indicate a more than 90% decrease in transcript expression. In addition, a modest decrease in Foxa2 expression is seen. (J:284174)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any 9030622O22Rik Mutation: 1 strain or line available

References

• Original: J:284174 Swarr DT, et al., The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration. Genes Dev. 2019 Jun 1;33(11-12):656-668
• All: 1 reference(s)