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Skor1em1(IMPC)J
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Skor1em1(IMPC)J
Name: SKI family transcriptional corepressor 1; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6385903
Gene: Skor1  Location: Chr9:63045452-63056243 bp, - strand  Genetic Position: Chr9, 33.96 cM
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CTGTACTTCCTGCATTAAAA and AGATTATCCCAAATCCACTA, which resulted in a 345 bp deletion beginning at Chromosome 9 position 63,143,267 bp and ending after 63,143,611 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000342989 (exon 3) and 248 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 768 and early truncation 92 amino acids later. There is a 2 bp insertion (AC) at the deletion site. (J:188991)
Inheritance:    Not Specified
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Skor1 Mutation:  18 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory