Nudt12^em1Rspi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nudt12^em1Rspi
• Name: nudix hydrolase 12; endonuclease-mediated mutation 1, Ramesh S Pillai
• MGI ID: MGI:6382616
• Synonyms: Nudt12^em1Embrp
• Gene: Nudt12 Location: Chr17:59307104-59320317 bp, - strand Genetic Position: Chr17, 30.64 cM, cytoband E1.1
• Alliance: Nudt12^em1Rspi page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1/J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 6 deleted 58 bp, containing the critical catalytic residues of the Nudix motif. Western blot analysis confirmed the absence of protein expression in the liver and kidney. (J:282288)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nudt12 Mutation: 22 strains or lines available

References

• Original: J:282288 Wu H, et al., Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs. Cell Rep. 2019 Dec 24;29(13):4422-4434.e13
• All: 1 reference(s)