Ywhae^tm2.2Awb
Targeted Allele Detail

Summary

• Symbol: Ywhae^tm2.2Awb
• Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; targeted mutation 2.1, Anthony Wynshaw-Boris
• MGI ID: MGI:6380689
• Gene: Ywhae Location: Chr11:75623695-75656671 bp, + strand Genetic Position: Chr11, 45.92 cM, cytoband B2
• Alliance: Ywhae^tm2.2Awb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281426
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3 and a second loxP site downstream of exon 4 followed by an FRT-flanked neomycin resistance (neo) cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed exons 3 and 4. (J:281426)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ywhae Mutation: 62 strains or lines available

References

• Original: J:281426 Eisa AA, et al., YWHA (14-3-3) protein isoforms and their interactions with CDC25B phosphatase in mouse oogenesis and oocyte maturation. BMC Dev Biol. 2019 Oct 22;19(1):20
• All: 3 reference(s)