Mxra8^em2Diam
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mxra8^em2Diam
• Name: matrix-remodelling associated 8; endonuclease-mediated mutation 2, Michael S Diamond
• MGI ID: MGI:6378754
• Synonyms: Mxra8^delta97
• Gene: Mxra8 Location: Chr4:155924137-155928545 bp, + strand Genetic Position: Chr4, 87.58 cM, cytoband E2
• Alliance: Mxra8^em2Diam page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 97-nucleotide deletion in the Ig-like domain 2 resulting in a truncation of the G-strand in domain 2. Western blot analysis confirmed absence of protein expression. (J:280585)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mxra8 Mutation: 32 strains or lines available

References

• Original: J:280585 Zhang R, et al., Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila. Cell Rep. 2019 Sep 3;28(10):2647-2658.e5
• All: 1 reference(s)