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Marveld1tm1.2Liy
Targeted Allele Detail
Nomenclature
Symbol: Marveld1tm1.2Liy
Name: MARVEL (membrane-associating) domain containing 1; targeted mutation 1.2, Yu Li
MGI ID: MGI:6377092
Gene: Marveld1  Location: Chr19:42147400-42151703 bp, + strand  Genetic Position: Chr19, 35.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:279065
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 1 via homologous recombination. Recombinase mediated recombination removed exon 1 and the pgk-neo cassette. (J:279065, J:280829)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Marveld1 Mutation:  13 strains or lines available
References
Original:  J:279065 Liu W, et al., MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell Death Dis. 2018 Sep 24;9(10):999
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory