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Targeted Allele Detail
Symbol: Phf8tm1.1Cdcn
Name: PHD finger protein 8; targeted mutation 1.1, Charlie Degui Chen
MGI ID: MGI:6370001
Gene: Phf8  Location: ChrX:150303668-150416855 bp, + strand  Genetic Position: ChrX, 68.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:258245
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 7 and 8, encoding the code region of the JmjC demethylase domain, were flanked by loxP sites. A FRT-flanked neomycin resistance gene was inserted downstream of exon 8 before the second loxP site. Cre-mediated recombination deleted exons 7 and 8 and the selection cassette in the germline. Western blot and immunostaining on brains confirmed absence of protein. (J:258245, J:280387)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phf8 Mutation:  14 strains or lines available
Original:  J:258245 Chen X, et al., Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway. Nat Commun. 2018 Jan 9;9(1):114
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory