Tg(RBP3-Prph2*)#Naash
Transgene Detail

Summary

• Symbol: Tg(RBP3-Prph2*)#Naash
• Name: transgene insertion, Muna I Naash
• MGI ID: MGI:6367824
• Synonyms: R172W
• Transgene: Tg(RBP3-Prph2*)#Naash Location: unknown
• Alliance: Tg(RBP3-Prph2*)#Naash page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(RBP3-Prph2*)#Naash expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prph2 (MGI:102791)	human promoter, mouse cDNA with p.R172W and p.P341Q mutations

• Mutation details: The transgene insert contains the following elements: the human interstitial retinol binding protein 3 promoter, the mouse Prph cDNA with two mutations (p.R172W and p.P341Q), and SV40 poly(A) signal sequence. The Arg172Trp mutation mimics the mutation found in some human patients presenting with retinal degeneration. The Pro341Gln mutation was made so the peptide can be identified by monoclonal antibody 3B6. (J:92815)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:92815 Ding XQ, et al., The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice. Hum Mol Genet. 2004 Sep 15;13(18):2075-87
• All: 6 reference(s)