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Mirc33tm1.1Wtsi
Targeted Allele Detail
Summary
Symbol: Mirc33tm1.1Wtsi
Name: microRNA cluster 33, including Mir29a through Mir29b-1; targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI ID: MGI:6367594
Synonyms: miR-29a/b1-
Gene: Mirc33  Location: Chr6:31039595-31040028 bp  Genetic Position: Chr6, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:267719
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: Sanger miRNA knockouts
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsMir29a and Mir29b1 in this microRNA cluster were replaced via homologous recombination with a puromycin/thymidine kinase fusion gene under the control of EM7/PGK promoters. The inserted selection cassette was flanked by loxP and F3/FRT sites. Cre-mediated recombination excised the replacement cassette. (J:174268, J:267719)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mirc33 Mutation:  0 strains or lines available
References
Original:  J:174268 Prosser HM, et al., A resource of vectors and ES cells for targeted deletion of microRNAs in mice. Nat Biotechnol. 2011 Aug 7;29(9):840-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory