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Targeted Allele Detail
Symbol: Tc(HSA17)1Mdk
Name: transchromosomal, human 17, line 1, Michael Koob
MGI ID: MGI:6363617
Synonyms: MAPT-GR
Gene: Tc(HSA17)1Mdk  Location: unknown  Genetic Position: Chr11, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  PRX-B6N (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intergenic deletion
Tc(HSA17)1Mdk expresses 2 genes
Mutation detailsA 157 kb deletion on mouse chromosome 11 stretching from, but not including, Crhr1 to Kansl1 is replaced by a syntenic 190 kb region from human chromosome 17 (HSA17). In this transchromosomal (Tc) strain, the mouse Sppl2c (signal peptide peptidase 2C) and Mapt (microtubule-associated protein tau) genes are replaced by human SPPL2C and MAPT genes and a loxN-flanked hygromycin cassette. Cre-mediated recombination removed the hygromycin cassette. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tc(HSA17)1Mdk Mutation:  1 strain or line available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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