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Trim58tm2313.1Arte
Targeted Allele Detail
Nomenclature
Symbol: Trim58tm2313.1Arte
Name: tripartite motif-containing 58; targeted mutation 2313.1, TaconicArtemis
MGI ID: MGI:6362941
Synonyms: Trim58fl
Gene: Trim58  Location: Chr11:58640465-58652404 bp, + strand  Genetic Position: Chr11, 36.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:279270
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 3-5 were flanked by loxP sites and a FRT-flanked neomycin resistance gene and F3-flanked puromycin resistance gene were inserted into intron 2 and intron 5, respectively. Flp-mediated recombination removed the selection makers leaving exons 3-5 floxed. (J:279270)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim58 Mutation:  0 strains or lines available
References
Original:  J:279270 Eyking A, et al., TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells. J Immunol. 2019 Sep 15;203(6):1636-1649
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory