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AW112010em2Flv
Endonuclease-mediated Allele Detail
Summary
Symbol: AW112010em2Flv
Name: expressed sequence AW112010; endonuclease-mediated mutation 2, Richard A Flavell
MGI ID: MGI:6358209
Synonyms: Aw112010Stop
Gene: AW112010  Location: Chr19:11024976-11027930 bp, - strand  Genetic Position: Chr19, 7.59 cM
Alliance: AW112010em2Flv page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA small 14-nucleotide sequence (TAATTAATTAATTA) was targeted into the second exon of the Aw112010 gene using CRISPR/Cas9. This sequence contains a stop codon in all three frames and will also frameshift any protein-coding sequene upon insertion. (J:267975)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any AW112010 Mutation:  6 strains or lines available
References
Original:  J:267975 Jackson R, et al., The translation of non-canonical open reading frames controls mucosal immunity. Nature. 2018 Dec;564(7736):434-438
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory