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Mapkapk2tm1.1Gkl
Targeted Allele Detail
Summary
Symbol: Mapkapk2tm1.1Gkl
Name: MAP kinase-activated protein kinase 2; targeted mutation 1.1, George Kollias
MGI ID: MGI:6357678
Synonyms: MK2f, MK2fl
Gene: Mapkapk2  Location: Chr1:130981437-131025563 bp, - strand  Genetic Position: Chr1, 56.89 cM, cytoband E4
Alliance: Mapkapk2tm1.1Gkl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:262876
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe allele contains loxP sites 1/2 flanking a neomycin resistance gene fragment and loxP sites 2/3 flanking the area between exons 2-5. Cre-mediated recombination removed the selection cassette. (J:262876)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapkapk2 Mutation:  36 strains or lines available
References
Original:  J:262876 Henriques A, et al., Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5546-E5555
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory