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Slc10a1tm1Tac
Targeted Allele Detail
Nomenclature
Symbol: Slc10a1tm1Tac
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1; targeted mutation 1, Taconic
MGI ID: MGI:6356556
Synonyms: Slc10a1-
Gene: Slc10a1  Location: Chr12:80999959-81015479 bp, - strand  Genetic Position: Chr12, 37.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:274149
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced by a beta-galactosidase/puromycin (betageo/puro) selection cassette. Western blot analysis revealed absence of a glycosylated form of the protein in liver plasma membranes of homozygous mutant mice. Immunofluorescence staining confirmed the absence of protein signal in fresh frozen liver tissue. (J:274149)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc10a1 Mutation:  16 strains or lines available
References
Original:  J:274149 Slijepcevic D, et al., Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. Hepatology. 2015 Jul;62(1):207-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory