Ythdf1^tm1.1Sjj
Targeted Allele Detail

Summary

• Symbol: Ythdf1^tm1.1Sjj
• Name: YTH N6-methyladenosine RNA binding protein 1; targeted mutation 1.1, Sheng-Jian Ji
• MGI ID: MGI:6356298
• Synonyms: Ythdf1^fl
• Gene: Ythdf1 Location: Chr2:180546170-180562729 bp, - strand Genetic Position: Chr2, 103.5 cM
• Alliance: Ythdf1^tm1.1Sjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276416
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT-flanked neomycin resistance gene cassette coupled with a loxP site were inserted in intron 3 and intron 4, respectively. The FRT-flanked neomycin selectin cassette was removed via FLP-mediated recombination in the germline. (J:276416)

Expression

In Mice Carrying this Mutation:

15 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ythdf1 Mutation: 36 strains or lines available

References

• Original: J:276416 Zhuang M, et al., The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Res. 2019 May 21;47(9):4765-4777
• All: 3 reference(s)