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Rnf186em1Ktak
Endonuclease-mediated Allele Detail
Summary
Symbol: Rnf186em1Ktak
Name: ring finger protein 186; endonuclease-mediated mutation 1, Kiyoshi Takeda
MGI ID: MGI:6343557
Synonyms: Rnf186A117T
Gene: Rnf186  Location: Chr4:138694430-138695676 bp, + strand  Genetic Position: Chr4, 70.57 cM, cytoband D3
Alliance: Rnf186em1Ktak page
Mutation
origin
Strain of Origin:  B6D2F1
Mutation
description
Allele Type:    Endonuclease-mediated (Modified isoform(s))
Mutation:    Nucleotide substitutions
 
Mutation detailsThe codon for alanine at the 117th position (corresponding to the 64th position in human RNF186) was substituted with a codon encoding threonine using the CRISPR/Cas9 system. (J:258197)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnf186 Mutation:  11 strains or lines available
References
Original:  J:258197 Fujimoto K, et al., Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol. 2017 Mar;10(2):446-459
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory