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Bcas1tm1Himo
Targeted Allele Detail
Nomenclature
Symbol: Bcas1tm1Himo
Name: breast carcinoma amplified sequence 1; targeted mutation 1, Hisashi Mori
MGI ID: MGI:6343403
Synonyms: BCAS1-
Gene: Bcas1  Location: Chr2:170346991-170427845 bp, - strand  Genetic Position: Chr2, 91.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:242041
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA point mutation 12 bases downstream of adenine of the start codon was introduced to generate an in-frame stop codon. A mouse phosphoglycerate kinase promoter-driven neomycin resistantance gene (pgkneo) and a prokaryotic em7 promoter-driven zeocin-resistant gene (em7zeo) was inserted downstream of the engineered point mutation. Western blot analysis confirmed the absence of protein expression in the cerebral cortex and sciatic nerve of homozygote mutant mice. (J:242041)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcas1 Mutation:  7 strains or lines available
References
Original:  J:242041 Ishimoto T, et al., Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain. Glia. 2017 May;65(5):727-739
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory