Arhgap31^tm1.2Itl
Targeted Allele Detail

Summary

• Symbol: Arhgap31^tm1.2Itl
• Name: Rho GTPase activating protein 31; targeted mutation 1.2 InGenious Targeting Laboratory
• MGI ID: MGI:6343385
• Synonyms: CdGAP^-
• Gene: Arhgap31 Location: Chr16:38418705-38533397 bp, - strand Genetic Position: Chr16, 26.87 cM, cytoband B4
• Alliance: Arhgap31^tm1.2Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253757
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was deleted in the germline via Cre-mediated recombination of flanking loxP sites. Western blot analysis confirmed the absence of protein expression in lung, brain, and heart tissue lysates from homozygous mutant mice. (J:253757)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap31 Mutation: 38 strains or lines available

References

• Original: J:253757 Caron C, et al., CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis. Sci Rep. 2016 Jun 7;6:27485
• All: 1 reference(s)