Gmnc^tm1.1Strc
Targeted Allele Detail

Summary

• Symbol: Gmnc^tm1.1Strc
• Name: geminin coiled-coil domain containing; targeted mutation 1.1, Travis Stracker
• MGI ID: MGI:6343381
• Synonyms: Gemc1^-
• Gene: Gmnc Location: Chr16:26775985-26810424 bp, - strand Genetic Position: Chr16, 18.56 cM
• Alliance: Gmnc^tm1.1Strc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231675
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were flanked by loxP sites. Cre mediated recombination removed exons 3 and 4. RT-qPCR analysis confirmed the absence of mRNA expression in multiple tissues of homozygous mutant mice, including trachea, lung, testis, oviduct, ovary, cortex and cerebellum. (J:231675)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gmnc Mutation: 24 strains or lines available

References

• Original: J:231675 Terre B, et al., GEMC1 is a critical regulator of multiciliated cell differentiation. EMBO J. 2016 May 2;35(9):942-60
• All: 5 reference(s)