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Plekhf1tm1.1Caox
Targeted Allele Detail
Nomenclature
Symbol: Plekhf1tm1.1Caox
Name: pleckstrin homology domain containing, family F (with FYVE domain) member 1; targeted mutation 1.1, Xuetao Cao
MGI ID: MGI:6343232
Synonyms: Lapffl
Gene: Plekhf1  Location: Chr7:38220654-38227994 bp, - strand  Genetic Position: Chr7, 25.36 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277440
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank exon 2. An FRT-flanked neomycin selection cassette was removed via FLP-mediated recombination. (J:277440)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plekhf1 Mutation:  10 strains or lines available
References
Original:  J:277440 Li T, et al., An endosomal LAPF is required for macrophage endocytosis and elimination of bacteria. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12958-12963
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory