Pth2r^tm1.1Tbu
Targeted Allele Detail

Summary

• Symbol: Pth2r^tm1.1Tbu
• Name: parathyroid hormone 2 receptor; targeted mutation 1.1, Ted B Usdin
• MGI ID: MGI:6330764
• Gene: Pth2r Location: Chr1:65321215-65428403 bp, + strand Genetic Position: Chr1, 33.05 cM, cytoband C3
• Alliance: Pth2r^tm1.1Tbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251444
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 4 and a neomycin resistance gene cassette and a second loxP site into intron 5. The floxed exon 5 and the neo cassette were deleted through subsequent cre-mediated recombination. Exon 5 contains a transmembrane domain and its deletion causes a frameshift, creating a null allele. (J:251444)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pth2r Mutation: 32 strains or lines available

References

• Original: J:251444 Dimitrov E, et al., Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons. J Comp Neurol. 2010 Nov 1;518(21):4375-94
• All: 2 reference(s)