Tg(KRT14-VP16/NR1I2)13Sdub
Transgene Detail

Summary

• Symbol: Tg(KRT14-VP16/NR1I2)13Sdub
• Name: transgene insertion 13, Sandrine Dubrac
• MGI ID: MGI:6330734
• Synonyms: K14-VPPXR
• Transgene: Tg(KRT14-VP16/NR1I2)13Sdub Location: unknown
• Alliance: Tg(KRT14-VP16/NR1I2)13Sdub page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-VP16/NR1I2)13Sdub expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NR1I2 (8856)

  Nr1i2

  (MGI:1337040)

• Mutation details: The human pregnane X receptor cDNA linked to the herpes simplex VP16 domain at the 5' end is under the control of the human keratin 14 promoter, generating a constitutively expressed fusion protein in the basal layer of murine stratified squamous epithelia. (J:258435)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:258435 Elentner A, et al., Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response. J Invest Dermatol. 2018 Jan;138(1):109-120
• All: 1 reference(s)