Tg(Myh6-BAG3*P209L)#Mswi
Transgene Detail
|
Symbol: |
Tg(Myh6-BAG3*P209L)#Mswi |
Name: |
transgene insertion, Monte S Willis |
MGI ID: |
MGI:6324028 |
Transgene: |
Tg(Myh6-BAG3*P209L)#Mswi Location: unknown
|
Alliance: |
Tg(Myh6-BAG3*P209L)#Mswi page
|
|
|
Transgene Type: |
|
Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(Myh6-BAG3*P209L)#Mswi expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
BAG3 (9531) |
|
Contains the P209L mutation found in myofibrillar myopathy patients |
|
|
|
Mutation details: The human BAG3 cDNA with the P209L missense mutation is under the control of the alpha-MHC promoter. This mutation has been identified in myofibrillar myopathy patients. Transgene expression levels are approximately 2-fold of wild-type levels in the heart. The pound (#) sign is used when line number is not specifies or lines are pooled.
(J:234278)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:234278 Quintana MT, et al., Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. Am J Pathol. 2016 Aug;186(8):1989-2007 |
All: |
1 reference(s) |
|