Prss3b^tm2.1Satom
Targeted Allele Detail

Summary

• Symbol: Prss3b^tm2.1Satom
• Name: serine protease 3B; targeted mutation 2.1, Miklos Sahin-Toth
• MGI ID: MGI:6307817
• Synonyms: T7 D23A,K24G
• Gene: Prss3b Location: Chr6:41007202-41012443 bp, - strand Genetic Position: Chr6, 19.1 cM
• Alliance: Prss3b^tm2.1Satom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267764
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Exon 2 was modified to produce the amino acid substitution of alanine for aspartic acid at position 23 (D23A) and glycine for lysine at position 24 (K24G) to abolish trypsinogen activation. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:267764)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss3b Mutation: 22 strains or lines available

References

• Original: J:267764 Geisz A, et al., A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation. Nat Commun. 2018 Nov 28;9(1):5033
• All: 1 reference(s)