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Endonuclease-mediated Allele Detail
Symbol: Mtorem1Vic
Name: mechanistic target of rapamycin kinase; endonuclease-mediated mutation 1, Gabriel Victora
MGI ID: MGI:6295460
Synonyms: MtorF2108L
Gene: Mtor  Location: Chr4:148533068-148642140 bp, + strand  Genetic Position: Chr4, 78.76 cM, cytoband E1
Strain of Origin:  C57BL/6
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Nucleotide substitutions
Mutation detailsCRISPR-targeting of exon 45 engineered nucleotide substitutions to produce a G to C silent mutation creating an AfIII reaction enzyme site, C to A resulting in the amino acid substitution of leucine for phenylalanine at position 2108 (F2108L) and several silent mutations to prevent Cas9 recutting. The amino acid substitution produces rapamycin resistance. (J:259205)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtor Mutation:  80 strains or lines available
Original:  J:259205 Ersching J, et al., Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. Immunity. 2017 Jun 20;46(6):1045-1058.e6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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