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Tbk1em8Lutzy
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Tbk1em8Lutzy
Name: TANK-binding kinase 1; endonuclease-mediated mutation 8, Cathy Lutz
MGI ID: MGI:6295419
Synonyms: Tbk1N22D
Gene: Tbk1  Location: Chr10:121382360-121422692 bp, - strand  Genetic Position: Chr10, 69.84 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/Cas9 genome editing is used to introduce a AATto GAT resulting in an N22D amino acid substitution in exon 6. In humans, the N22D substitution is associated with amyotrophic lateral sclerosis. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbk1 Mutation:  42 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory