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Gnao1em1Rneu
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Gnao1em1Rneu
Name: guanine nucleotide binding protein, alpha O; endonuclease-mediated mutation 1, Richard R Neubig
MGI ID: MGI:6295353
Synonyms: Gnao1G203R
Gene: Gnao1  Location: Chr8:93810561-93969388 bp, + strand  Genetic Position: Chr8, 45.94 cM
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/Cas9 technology generated a GGG to CGC change in exon 6 resulting in a glycine to arginine gain of function mutation at amino acid 203. (J:271137)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnao1 Mutation:  4 strains or lines available
References
Original:  J:271137 Feng H, et al., Mouse models of GNAO1-associated movement disorder: Allele- and sex-specific differences in phenotypes. PLoS One. 2019;14(1):e0211066
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory