Gnao1^em1Rneu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gnao1^em1Rneu
• Name: guanine nucleotide binding protein, alpha O; endonuclease-mediated mutation 1, Richard R Neubig
• MGI ID: MGI:6295353
• Synonyms: Gnao1^G203R
• Gene: Gnao1 Location: Chr8:94536781-94696016 bp, + strand Genetic Position: Chr8, 45.94 cM
• Alliance: Gnao1^em1Rneu page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a GGG to CGC change in exon 6 resulting in a glycine to arginine gain of function mutation at amino acid 203. (J:271137)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnao1 Mutation: 29 strains or lines available

References

• Original: J:271137 Feng H, et al., Mouse models of GNAO1-associated movement disorder: Allele- and sex-specific differences in phenotypes. PLoS One. 2019;14(1):e0211066
• All: 1 reference(s)