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Nucks1tm1.2Vter
Targeted Allele Detail
Nomenclature
Symbol: Nucks1tm1.2Vter
Name: nuclear casein kinase and cyclin-dependent kinase substrate 1; targeted mutation 1.2, Vinay Tergaonkar
MGI ID: MGI:6294929
Synonyms: Nucks1-
Gene: Nucks1  Location: Chr1:131910534-131936321 bp, + strand  Genetic Position: Chr1, 57.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:211777
Parent Cell Line:  EGR-G01 (ES Cell)
Strain of Origin:  (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 4. The neo cassette was removed through subsequent flp-mediated recombination. Exon 4 was deleted through subsequent cre-mediated recombination. Western blot analysis showed an absent of expression in mouse embryonic fibroblasts, liver, and epididymal adipose tissues. (J:211777)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nucks1 Mutation:  49 strains or lines available
References
Original:  J:211777 Qiu B, et al., NUCKS Is a Positive Transcriptional Regulator of Insulin Signaling. Cell Rep. 2014 Jun 26;7(6):1876-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory